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Bimatoprost is a synthetic prostamide, structurally linked to prostaglandins F2α. However, the action of reducing IOP in this drug is not related to prostaglandin receptors, but selectively simulating the effect of prostamides. The exact mechanism of action of bimatoprost is not known, because there are no receptors for it in the human body at present. The effect of PIO reduction is to increase the flow through the trabecular network and the uveoscleral flow of intraocular fluid. The effect of the drug starts to appear at about 4 hours after administration and reaches a maximum after 8-12 hours. Its duration is at least 24 hours. (more…)